Started in the year 1953 as part of Department of Mathematics, it became an independent department in 1970. The pioneers of the department are (Late) Professor K. Ramakrishna Pillai (First H O D), Professor V.K. Ignatius and Dr. A.M. Mathai (Canada). Former faculty includes (Late) Professor K.G. Panicker, Professor Thomas Mathew, Dr Yageen Thomas (Former Head, Department of Statistics, Kerala University) and Professor V.N. Sukumaran. It became a recognized research centre in 1997. Alumni like Dr N.Unnikrishnan Nair (Former VC, CUSAT), Dr. Bovas Abraham (Waterloo University, Canada), Dr. C.P. Kartha (Michigan State University, USA), Dr. N.J. Kurian (Former Advisor, Planning Commission of India), Dr. K.K. Jose (Principal, St. Thomas College, Pala), Sri T.K. Jose IAS (Chairman, Coconut Development Board of India) and Sri James Mathew ISS have brought glory to the department through their meritorious service. The department has been very active in teaching, research, training and consultancy and organized a number of international conferences, workshops etc. It is a DST-FIST sponsored department and was sanctioned MSc Biostatistics under UGC Innovative Programme in emerging interdisciplinary areas of teaching and research.