Bio Sketch

1

PhD in Biotechnology

Rajiv Gandhi Centre for Biotechnology, Trivandrum [University of Kerala]

July 2015

M R Das Career award, July 2015

2

M.Sc. Biotechnology

St.Peter's College, Kolenchery-[Mahatma Gandhi University]

2002- 2004

70.4%

3

B.Sc. Zoology

St.Xavier's College, Vaikom- [Mahatma Gandhi University]

1999-2001

98.5% [M.G.University First Rank]

4

Pre- degree

Deva Matha College, Kuravilangadu- [Mahatma Gandhi University]

1996-1998

72%

5

S.S.L.C

[St.Emmanuel's H.S.Kothanalloor-Kerala Board of Examinations]

1996

76.8%

Cancer chemotherapy, chemosensitization, Bioprospecting

1

Rajiv Gandhi Centre for Biotechnology, Trivandrum

PhD Scholar

July 2008 to July 2015

2

Rajiv Gandhi Centre for Biotechnology, Trivandrum

Junior Research Fellow

January 2007 to June 2008

3

K.E. College, Mannanam, Kottayam

Lecturer

February 2006 to January 2007

4

C.M.S. College, Kottayam

Lecturer

July 2004 to July 2005

5

Rajiv Gandhi Centre for Biotechnology, Trivandrum

Senior Research Fellow

August 2015 to January 2016

6

Department of Zoology, St.Thomas College, Palai

Assistant Professor

27 January 2016

7

Department of Zoology, St.Thomas College, Palai

Assistant Professor Stage II

27 January 2020

1

Jayesh Antony,A Shabna,S. Sankar,Minakshi Saikia, Ruby John Anto Pharmacological attenuation of melanoma by tryptanthrin pertains to the suppression of MITF-M through MEK/ERK signaling axis. Cellular and Molecular Life Sciences 79:478

2022

2

Chitosan Encapsulation Enhances the Bioavailability and Tissue Retention of Curcumin and Improves its Efficacy in Preventing B[a]P-induced Lung Carcinogenesis.Vijayakurup V1, Thulasidasan AT1, Shankar G M1,2, Retnakumari AP1, Nandan CD3, Somaraj J1, Antony J1, Alex VV1, Vinod BS1, Liju VB1, Sundaram S4, Kumar GSV3, Anto RJ5.Cancer Prev Res (Phila). 2019 Apr;12(4):225-236. doi: 10.1158/1940-6207.CAPR-18-0437. Epub 2019 Feb 13.

2019

3

Evaluation of uttroside B, a saponin from Solanum nigrum Linn, as a promising chemotherapeutic agent against hepatocellular carcinoma, Lekshmi R. Nath, Jaggaiah N. Gorantla, Arunkumar T. Thulasidasan,Vinod Vijayakurup, Shabna Shah, Shabna Anwer, Sophia M. Joseph, Jayesh Antony, Kollery Suresh Veena, Sankar Sundaram, Udaya K. Marelli, Ravi S. Lankalapalli and Ruby John Anto, Scientific Reports, October 2016 [Accepted]

2016

4

miR cluster 143/145 directly targets Nrl and regulates rod photoreceptor development, Sreekumaran Sreekanth; Vazhanthodi A Rasheed, Ph.D.; Lalitha Soundararajan; Jayesh Antony, Ph.D.; Minakshi Saikia; Krishnankutty C Sivakumar; Ani V Das, PhD, Molecular Neurobiology, October 2016 [Accepted]

2016

5

Antioxidant and cytotoxic effects of essential oil, water and ethanol extracts of major Indian spices Shamina Azeez*, Jayesh Antony**, N.K. Leela and Ruby John Anto** Indian J. Hort. 73(2), June 2016: 229-237DOI : 10.5958/0974-0112.2016.00053.0

2016

6

Lekshmi R. Nath, Jaggaiah N. Gorantla, Sophia Margaret Joseph, Jayesh Antony, Sanu Thankachan, Darsan B. Menon, S. Sankar, Ravi S. Lankalapalli and Ruby John Anto. Kaempferide, the most active among the four flavonoids isolated and characterized from Chromolaena odorata, induces apoptosis in cervical cancer cells while being pharmacologically safe. RSC Adv., 2015,5, 100912-100922, DOI: 10.1039/C5RA19199H

2015

7

Vineshkumar T. Puliyappadamba, Arun Kumar T Thulasidasan, V Vinod, Jayesh Antony, Smitha V. Bava, A Shabna, S Sankar and Ruby John Anto. Curcumin inhibits B[a]PDE-induced procarcinogenic signals in lung cancer cells, and curbs B[a]P-induced mutagenesis and lung carcinogenesis. Biofactors 2015 Dec 8. doi: 10.1002/biof.1244

2015

8

Jayesh Antony, Minakshi Saikia, Vino T. Cheriyan, Nishanth Kumar S and Ruby John Anto. Sesbania: A Prospective Candidate to be Excavated for Anticancer Drugs. The Natural Products Journal, 5(4): 273-287. DOI: 10.2174/1872211310999151110155644 (2015).

2015

9

Antony, J. et al. DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria. Sci. Rep. 5, 11107; doi: 10.1038/srep11107 (2015)

2015

10

BS Vinod, *J Antony, HH Nair, VT Puliyappadamba, M Saikia, S Shyam Narayanan, A Bevin and R John Anto. Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil. Cell Death and Disease 2013 February; 4(2): e505. Published online 2013 February 21. doi: 10.1038/cddis.2013.26 (*Sharing Equal First authorship)

2013

11

Haritha H Nair, Balachandran S Vinod, Jayesh Antony, Minakshi Saikia, Ruby John Anto, Curcumin sensitizes breast cancer cells to 5-FU through thymidylate synthase- dependent downregulation of NF-κB (Abstract). Journal of Carcinogenesis, Vol.11, Supplement 1, 2012, pp-S31

2012

12

M. S. R. Murty, B. Ramalingeswara Rao, Kesur R. Ram, J. S. Yadav, Jayesh Antony and Ruby John Anto, Synthesis and preliminary evaluation activity studies of novel 4- (aryl/heteroaryl-2-ylmethyl) 6-phenyl-2-[3-(4-substitutedpiperazine-1-yl)propyl] pyridazin-3(2H)- one derivatives as anticancer agents. Medicinal Chemistry Research. October 2012, Volume 21, Issue 10, pp 3161-3169.

2012

13

Jayesh Antony and Ruby John Anto. A molecular approach to Skin Cancer. Amala Research Bulletin 28 (2008), Pp141-152

2008

14

Parry Varghese., Rojimon. P. Thomas., Jayesh Antony.,Simimol Cyriac.,Rajasekharan. and Manuel Thomas. Bacterial pathogens associated with liquid wastes in a nosocomial environment. Proce. Of Ind. Env. Congress, 2006. Amritha Vishwa Vidyapeedam

2006

15

Manuel Thomas., Rojimon. P. Thomas., Jayesh Antony., K. Rajasekharan. and Raja.M.P. A study on microbial contamination in domestic environment.S.B.Academic Review.Vol-XIII.Part-1.Pp.63-66

2006

1

The Enzymes, Volume 37, 2015

2015

Elsevier

1874-6047

Jayesh Antony • G. Mohan Shankar • Ruby John Anto . Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions, Pages 43–72, Chapter 2.

2

Anticancer properties of fruits and vegetables: A scientific review

2014

World Scientific Publishing Co

978-981-4508-88-9

*Jayesh Antony, *Minakshi Saikia and Ruby John Anto. Phytochemicals from Fruits and Vegetables as potential anti-cancer agents: special reference to skin cancer, Chapter, pp 277-307

3

Pandemics and Global Health

2021

Nova Science Publishers, USA

978-1-68507-261-2

Chapter 4. The Role of Vaccines in Public Health

1

26th Kerala Science Congress

Contributed

Wayanad, Kerala

28-31 January 2014

National

Identification and characterization of Tryptanthrin, the active principle from Wrightia tinctoria and the validation of its anticancer efficacy in vitro and in vivo. Jayesh Antony, Minakshi Saikia And Ruby John Anto, Cancer Research Program, Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram-695014

2

RGCB Merit Award-2013

Contributed

Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram-695014

November, 2013

Regional

Molecular Evaluation of Anticancer Properties of the Active Principle/s from the Indegenous Medicinal Plant Wrightia tinctoria. Jayesh Antony and Ruby John Anto.

3

33rd Annual convension of Indian Association for Cancer Research Discovery, Innovation and Translation in Cancer Research

Contributed

Kollam, Kerala

February 13-15, 2014

National

Jayesh Antony, Minakshi Saiki, Sophia Margeret Joseph, Vinod.V., Lekshmi. R. Nath, Mohana Rao Katiki, M.S.R. Murty and Ruby John Anto. In vitro and in vivo validation of anticancer efficacy of tryptanthrin, isolated from Wrightia tinctoria [Roxb.] R.Br.

4

3rd International Conference [Carcinogenesis 2012] on frontiers in carcinogenesis and preventive oncology: molecular mechanisms to therapeutics

Contributed

New Delhi, India

November 19-21, 2012

International

Haritha H Nair, Balachandran S Vinod, Jayesh Antony, Minakshi Saikia, Ruby John Anto, Curcumin sensitizes breast cancer cells to 5-FU through thymidylate synthase- dependent downregulation of NF-κB

5

International Conference on Advances in Biological Sciences

Contributed

Kannur University

March 2012

International

Jayesh Antony, Sophia Margeret Joseph, Lekshmi. R. Nath, Harsha Chandran and Ruby John Anto. Isolation, identification and molecular characterization of a potential anticancer compound Wrightiadione from the indigenous medicinal plant, Wrightia tinctoria.

6

Indian Academy of Cancer research Satellite Meeting

Participation

Amala Cancer Research Centre, Trichur

February 2011

National

Jayesh Antony, Sophia Margeret Joseph, Lekshmi. R. Nath, Harsha Chandran and Ruby John Anto. A study on the anticancer properties of the active principle/s from indigenous medicinal plant Wrightia tinctoria [Roxb.] R. Br.

7

International Cancer Research Sympossium

Contributed

Rajiv Gandhi Centre for Biotechnology, Trivandrum

December 2010

International

Jayesh Antony, Sophia Margeret Joseph, Lekshmi. R. Nath, Harsha Chandran and Ruby John Anto. A study on the anticancer properties of the active principle/s from indigenous medicinal plant Wrightia tinctoria [Roxb.] R. Br.

8

International Conference of Science and Technology

Participation

S.B.College,Changanacherry

2005

International

A comparative study on the antimicrobial effect of selected oils.

9

International Conference of Science and Technology

Participation

S.B.College, Changanacherry

2005

International

Jayesh Antony and Deepa Alex. A study on extraction of metabolites from fungi.

10

International Conference of Science and Technology

Participation

S.B. College, Changanacherry

2005

International

Jayesh Antony and Rakesh Kumar T. Pollution in bottled water- An appraisal.

11

International Conference on Neutraceuticals

Participation

Cochin, Kerala, India

9-11 September 2016

International

Evaluation of Tryptanthrin as an effective chemosensitizer for Dacarbazine chemotherapy against malignant melanoma, Minakshi Saikia, Jayesh Antony, Shabna A and Ruby John Anto

12

36th Annual Conference of Indian Association for Cancer research, The 21st Century War on Cancer

Contributed

Amala Cancer Research Centre, Thrissur

9-11 February 2017

National

Mechanistic Evaluation and In vivo validation of tryptanthrin as a potent molecule against malignant melanoma

13

International Conference on Neutraceuticals and Chronic Diseases

Invited

Organized by Society for neutraceuticals and Chronic diseases

1-3 September 2017

International

Mechanistic Evaluation and In vivo validation of the Molecular Mechanism of tryptanthrin as an effective therapeutic agent against malignant melanoma, Shabna A, Jayesh Antony, Vinod V, Minakshi Saikia and Ruby John Anto

14

International Conference on Neutraceuticals and Chronic Diseases

Contributed

Organized by Society for neutraceuticals and Chronic diseases

1-3 September 2017

International

Evaluation of the chemotherapeutic and chemopreventive potential of Tryptanthrin against Non-Melanoma skin cancer, Mohan Sankar G, Jayesh Antony,Devika VS, Archana Keshavan and Ruby John Anto

15

International Conference on Neutraceuticals and Chronic Diseases

Contributed

Organized by Society for neutraceuticals and Chronic diseases

1-3 September 2017

International

Unravelling the Molecular Events Regulating the Therapeutic Potential of Tryptanthrin in Melanoma Chemotherapy, Shabna A, Jayesh Antony, Vinod V, Minakshi Saikia,Vidya Peter and Ruby John Anto

16

PRAGMA

Invited

Alphonsa College, Palai

01/03/2018

Regional

Drug Discovery in Cancer

17

New horizons in Cancer Treatment and Prevention: From Bench to Bedside (Jointly sponsored by DST

Contributed

SN College, Kollam

16th & 17th March 2018

National

Isolation of an antimelanoma compound Tryptanthrin from Wrighia tinctoria

18

31st Kerala Science Congress

Contributed

Fatima Mata National College, Kollam

2nd February 2019

Regional

Deciphering the molecular events regulated by tryptanthrin in melanoma, Shabna A, Ruby John Anto, Jayesh Antony, Vinod Vand Archana PR

19

32ndKerala Science Congress

Contributed

Yuvakshetra Institute of Management Studies, Mundur, Palakkad

25th-27th january 2020

Regional

Intrepreting the mechanism of action of Tryptanthrin, an anticancer compound from W.tinctoria against malignant melanoma, Shabna A, Ruby John Anto, Jayesh Antony, Vinod V,

20

Webinar

Invited

Post Graduate Department of Zoology, Deva Matha College, Kuravilangadu [Online]

25 June 2022

Regional

Sickle Cell Anaemia-Past to Present

1

M R Das Career award

For the professional achievements gained during the PhD tenure in Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 13th July 2015.

2

Best Research presentation award [RGCB Students Merit Award]

Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, November 2013

3

Best Poster Award

International Cancer research Symposium held at Rajiv Gandhi Centre for Biotechnology, Trivandrum, December 2010

4

Junior Research Fellowship

UGC-CSIR, December 2007

5

National Eligibility Test

UGC-CSIR, June 2006

6

National Eligibility Test

UGC-CSIR, June 2007

7

First rank in B.Sc. Zoology

Mahatma Gandhi University

8

Best Poster Award

International Conference on Advances in Biological Sciences held at Kannur University, March 2012

9

Best Oral Presentation award, as co-author of the work

32nd Kerala Science congress

1

Member, UG Board of Studies in Biotechnology, Mahatma Gandhi University, Kottayam

2021

2

Research Guide in Zoology and Biotechnology, Post Graduate Department of Botany, St.Thomas College, Palai

June 2022

1

Anti-Cancer Agents in Medicinal Chemistry

Reviewer

2

Proceedings of the National Academy of Sciences, Biological Sciences (NASB)

Reviewer

3

PLOS ONE

Reviewer

1

Orientation Programme

UGC-HRDC, University of Calicut

06-11-2019 to 26-11-22019

2

Two-week workshop on Research Methedology

College Development Counsil, MG University, Kottayam

03-12-2018 to 17-12-2018

3

Refresher Course in Material Science: Recombinant Memetics

UGC-HRDC, University of Calicut

21-10-2020 to 06-11-2020

4

ICAR sponsored Winter School on Recent Development in Taxonomic Techniques of marine Fishes for Conservation and Sustainable Fisheries Management

ICAR- Central Marine Fisheries Research Institute, Kochi

03-01-2022 to 23-01-2022